Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. when BUN level is elevated, the BUN/Creatinine ratio helps to determine if. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of renal (kidney) health. It is not considered as reliable as creatinine or BUN/creatinine ratio blood studies. The test is used to detect renal problems. Results of the BUN test are measured in milligrams per deciliter (mg/dL) in the United States and in millimoles per liter (mmol/L) internationally. Individual laboratories will have different reference ranges, as the assay used can vary between laboratories. Normal human adult blood should contain 6 to 20 mg/dL (2.1 to 7.1 mmol/L) of urea nitrogen. BUN/Creatinine ratio increases with age, and with decreasing muscle mass. The liver produces urea in the urea cycle as a waste product of the digestion of protein. The normal range for BUN/Creatinine ratio is anywhere between 5 20 mg/dL. Certain factors, such as dehydration, pregnancy, high or low protein intake, steroids, and aging can impact your levels without indicating a health risk.6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood. However, abnormal BUN levels don’t necessarily mean you have a kidney condition. A medication wouldn’t be recommended to lower BUN levels. A low-protein diet can also help lower BUN levels. Proper hydration is the most effective way to lower BUN levels. Keep in mind that some medications, such as certain antibiotics, can raise your BUN levels.ĭepending on your test results, your doctor may also run other tests to confirm a diagnosis or recommend treatments. Normal BUN levels for adults over 60 are slightly higher than normal levels for adults under 60. children 1 to 17 years old: 7 to 20 mg/dL.In general, normal BUN levels fall in the following ranges: It’s also important to note that each laboratory has different ranges for what’s normal. Normal BUN values tend to vary depending on gender and age. Results of a BUN test are measured in milligrams per deciliter (mg/dL).
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